Unraveling RNA helicases:
from molecules to cells
The Central Dogma of Molecular Biology states that DNA is the genetic blueprint, which is transcribed into RNA, then translated into functional protein. Although seemingly simplistic, this path of gene expression (DNA -> RNA -> Protein) is vastly complex within a cell, with multiple steps for regulation and many, many factors involved.
In the Fritz Lab, we aim to understand the complex, molecular processes of gene expression control, with a long-term goal of using this knowledge to modulate gene expression outcomes in human health and disease.
Our efforts are specifically focused on understanding the role of molecular machines known as RNA helicases in gene regulatory pathways. Current work in the lab focuses on the RNA helicase UPF1 and how it selects RNAs for nonsense-mediated decay, a specialized RNA decay pathway associated with one-third of human genetic diseases.
We invite you to explore our website to learn more about our team, our philosophy, and the research we do.